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Dr Wilfred Ndifon has proposed a solution to a 70-year old immunological mystery relating to the original antigenic sin. This complex problem has played havoc with efforts to fight infectious diseases, particularly in places such as Africa where people can suffer successive infections. Ndifon and Tolullah Oni are two of 12 Next Einstein Forum Fellows working to solve major challenges in health, education, big data and quantum theory using science, technology, engineering and mathematics. To read more about Dr. Ndifon’s breakthrough research, go to The Conversation.